fight cancer.This research could lead to improved cancer therapies for millions of people. The study was published in the journal Nature Communicationson May 14, 2021.The new method of stimulating immune cells to fight cancer will make immunotherapy even more effective.
Instead of using harmful chemicals or radiation, immunotherapy harnesses the patient’s immune system to prevent or eliminate cancer. The cancer treatment involves using T cells, a white blood cell playing a crucial role in immune responses to cancer.
Scientists compare Cytotoxic T cells to soldiers because they seek out and destroy targeted cancer cells. ADVERTISEMENT Many clinics use immunotherapy to treat various forms of cancer in the blood or blood-producing organs.
It’s been widely successful, but T cells have a more challenging time destroying cancer cells in solid tumors.Paolo Provenzano, the senior author of the study and a biomedical engineering associate professor at the University of Minnesota College of Science and Engineering, says the following:In this groundbreaking study, the researchers have worked on engineering the T cells to fight cancer more effectively. They’ve developed engineering design criteria that mechanically improve the cells to make them more capable of overcoming physical barriers.
By enhancing the immune cells’ ability to recognize and find cancer cells, they have a higher probability of destroying the tumor.Within fibrous masses of tumors, immune cells immediately slow down about two-fold due to the stiff nature of tumors. However, this new form of immunotherapy could help T cells maintain speed even in solid tumors.“This study is our first publication where we have identified some structural and signaling elements where
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