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UC Irvine Researchers Discover Breakthrough in Wound Healing

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Fscn1), becomes activated by a Grainyhead like 3 (GRHL3) gene. When this occurs, it relaxes the adhesion between wounded skin cells, and the protein-coding genes work to close the wound.GRHL3, an evolutionarily conserved gene, plays a considerable role in mammalian development.

If a mammal lacks this gene, various abnormalities can occur. These include rare conditions like spina bifida, defective epidermal barrier, defective eyelid closure, and soft-tissue syndactyly, which causes fused or webbed fingers in children.

ADVERTISEMENTThe study, published in the journal JCI Insight, reveals how GRHL3 activates Fscn1 to loosen adhesions between migrating keratinocytes during wound healing.

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