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Treatments for Depression and ADHD: New and Forthcoming Approaches

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November 13, 2023Rising rates of depression — a condition that often accompanies ADHD and other health concerns — have earned well-deserved concern and attention.

Here, Nelson M. Handal, M.D., DFAPA, reviews what we know about major depressive disorder and ADHD, explains the latest treatment options for depression, and touches on alternative treatments and therapies that may hold promise for future use.Q: What do we know about rates of ADHD and comorbid depression and mood disorders?There is significant comorbidity between ADHD, major depressive disorder (MDD), and other mood disorders across all age groups.

About 15% of children and adolescents with ADHD also have MDD, and anywhere from 7% to 17% of youth with ADHD also have bipolar disorder, according to our group’s review of available literature.12 In adults with ADHD, roughly 20% have MDD, and anywhere from 7% to 18% have bipolar disorder.3 About 25% of individuals with bipolar disorder that started in adulthood have ADHD, and the ADHD overlap is much higher — from 80% to 97% — when bipolar disorder begins in childhood.4Females with ADHD are at greater risk — by 2.5 times — for MDD compared to females without ADHD.5 In older adults, ADHD is associated with increased risk for depression.6Q: What explains the relationship between ADHD, depression, and mood disorders?Many factors are at play.

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Analysis on Homeopathy for ADHD Deemed ‘Invalid,’ ‘Biased’
November 6, 2023Pediatrics Research has retracted a paper on the effectiveness of using homeopathy to treat ADHD, citing “substantial concerns regarding the validity of the results presented in this article.” 1The original article “Is Homeopathy Effective for Attention Deficit and Hyperactivity Disorder? A Meta-Analysis” reported that “individualized homeopathy showed a clinically relevant and statistically robust effect in the treatment of ADHD.”1 This retraction directly challenges those results and addresses the concerns of critics, who argue that science does not support the use of homeopathy for addressing ADHD symptoms.The journal’s editor-in-chief issued the retraction after a review found four “deficiencies,” including the following:The paper’s retraction comes more than a year after critics first questioned the validity of the studies included in the meta-analysis. Shortly after the paper’s June 2022 publication, Edzard Ernst, M.D., Ph.D., MAE, FMedSci, FRSB, FRCP, FRCPEd, asked the editors of Pediatrics Research to add a caution notice or withdraw the paper.“We conclude that the positive result obtained by the authors is due to a combination of the inclusion of biased trials unsuitable to build evidence together with some major misreporting of study outcomes,” he wrote.In a follow-up letter sent in June 2023, Ernst wrote, “In our comment, we point out that the authors made a lot of errors — to say it mildly.
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