research and news: recent publications

All articles where research and news is mentioned

additudemag.com
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Analysis on Homeopathy for ADHD Deemed ‘Invalid,’ ‘Biased’
November 6, 2023Pediatrics Research has retracted a paper on the effectiveness of using homeopathy to treat ADHD, citing “substantial concerns regarding the validity of the results presented in this article.” 1The original article “Is Homeopathy Effective for Attention Deficit and Hyperactivity Disorder? A Meta-Analysis” reported that “individualized homeopathy showed a clinically relevant and statistically robust effect in the treatment of ADHD.”1 This retraction directly challenges those results and addresses the concerns of critics, who argue that science does not support the use of homeopathy for addressing ADHD symptoms.The journal’s editor-in-chief issued the retraction after a review found four “deficiencies,” including the following:The paper’s retraction comes more than a year after critics first questioned the validity of the studies included in the meta-analysis. Shortly after the paper’s June 2022 publication, Edzard Ernst, M.D., Ph.D., MAE, FMedSci, FRSB, FRCP, FRCPEd, asked the editors of Pediatrics Research to add a caution notice or withdraw the paper.“We conclude that the positive result obtained by the authors is due to a combination of the inclusion of biased trials unsuitable to build evidence together with some major misreporting of study outcomes,” he wrote.In a follow-up letter sent in June 2023, Ernst wrote, “In our comment, we point out that the authors made a lot of errors — to say it mildly.
additudemag.com
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Study: Trichotillomania, Excoriation, Other BFRBs Reduced with Habit Replacement Training
August 18, 2023Habit replacement training significantly reduced body-focused repetitive behaviors (BFRBs) for more than half of patients with excoriation (skin picking), trichotillomania (hair pulling), nail biting, lip-cheek biting, and other BFRBs, according to a six-week proof-of-concept study published in JAMA.1Of the study’s 268 participants, 53% of those who practiced habit replacement techniques reported improvement compared to 20% of the control group. Those who exhibited nail-biting benefited the most.Further, 80% of those who practiced habit replacement said they would recommend it to a friend with similar problems, and 86% reported overall satisfaction with the training, which substituted the pleasurable sensation of skin picking, nail-biting, or hair pulling with another action that feels good but isn’t harmful to the body.“BFRBs refer to recurrent and chronic behaviors inflicted upon the body (like trichotillomania and excoriation) that often result in physical damage,” said Roberto Olivardia, Ph.D., in the ADDitude webinar “Nail Biting! Skin Picking! Hair Pulling! Understanding Body-Focused Repetitive Behaviors with ADHD.”The TLC Foundation for Body-Focused Repetitive Behaviors estimates that BFRBs affect about 3% of people worldwide.
additudemag.com
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LSD, MDMA, Magic Mushrooms Clinical Trial Guidelines Released by FDA
July 7, 2023The Food and Drug Administration (FDA) has issued its first-ever draft guidance for clinical trials of psychedelic drugs to treat conditions including depression, mood disorders, anxiety, post-traumatic stress disorder, and substance use disorder.The guidance aims to address the unique challenges inherent in testing “classic psychedelics,” such as psilocybin (magic mushrooms) and lysergic acid diethylamide (LSD), and “entactogens” or “empathogens,” such as methylenedioxymethamphetamine (MDMA) for treating psychiatric conditions that failed to respond to other therapies. The FDA recommends clinical trial considerations regarding subject safety, data collection, manufacturing controls, and drug application requirements.Ultimately, “the goal is to help researchers design studies that will yield interpretable results that will be capable of supporting future drug applications,” said Tiffany Farchione, M.D., director of the Division of Psychiatry in the FDA’s Center for Drug Evaluation and Research, in a statement last month.In February 2022, researchers from Johns Hopkins Medicine reported that psilocybin-assisted therapy for major depressive disorder produced antidepressant effects up to 12 months after treatment.1Ari Tuckman, Psy.D., and Stephanie Sarkis, Ph.D., recently told ADDitude that using very low (micro) doses of psychedelics, such as LSD and psilocybin is gaining renewed attention as a treatment for anxiety and depression.
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