“We found weapons that are downstream of chemotherapy,” noted Peter, a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.“We think this is how multicellular organisms eliminated cancer before the development of the adaptive immune system, which is about 500 million years old,” Peter said in a statement in 2017. “It could be a fail-safe that forces rogue cells to commit suicide.
We believe it is active in every cell, protecting us from cancer.”However, they still needed to determine what caused the cells to self-destruct.
The team found that a sequence of six nucleotides (6mers) in small RNAs created a toxic environment for cancer. Nucleotides are present in both DNA as G, C, A, or T and U in RNA.In the study, Peter and his team tested all 4,096 combinations of nucleotide sequences in the 6mers.
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