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Depression Lower in Older Adults With Partner, Large Social Network, and Low Polygenic Risk Score – Psychiatry Advisor

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Having a high polygenic risk score for depression, being single, and having a small social network are all associated with a high risk of depression, according to a study in the American Journal of Geriatric Psychiatry.A total of 2279 people ≥55 years of age from the ongoing Longitudinal Aging Study of Amsterdam who had available genotyping data over a mean follow-up of 15 years were included in this study.

The researchers developed 2 risk scores for depression by calculating polygenic risk scores that were based on 23,032 single nucleotide polymorphisms associated with major depression.

Questionnaires were used to assess participants’ partner status, social network size, as well as received and given emotional support.

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